=======IHC Patterns=======

======Undifferentiated======

^  ^  Cytokeratin  ^  EMA  ^  LCA  ^  S-100  ^  Desmin/vimentin  ^  OCT 4/HCG/AFP/PLAP  ^  Chromogranin/synaptophysin  ^
| Carcinoma  |  +  |  +  |  -  |  S  |  -  |  S  |  S  |
| Melanoma  |  -, R  |  -  |  -  |  +  |  +  |  -  |  -  |
| Sarcoma  |  -  |  S  |  -  |  -  |  +  |  -  |  -  |
| Lymphoma  |  -  |  -, R  |  +  |  -  |  -  |  -  |  -  |
| Neuroendocrine carcinoma  |  +  |  +  |  -  |  -  |  -  |  -  |  +  |
| Germ cell tumor  |  -, R  |  -  |  -  |  -  |  -  |  +  |  -  |

S: sometimes positive \\ R: rarely positive

======Carcinoma======

^  Tumor type  ^  Immunohistochemical staining  ^
| Carcinoma | Positive: Pankeratin, AE 1/3, CAM 5.2, OSCAR, EMA \\ Negative: CD 45 \\ Variable: CK 7, CK 20, S-100, vimentin |
| Colorectal carcinoma | Positive: CK 20, CDX-2 \\ Negative: CK 7 |
| Adenocarcinoma (Lung) | Positive: TTF-1, napsin A, CK 7, mucicarmine, PAS-D \\ Negative: Thyroglobulin |
| Squamous cell carcinoma (Lung) | Positive: p 40, p 63, CK 5/6, desmoglein \\ Negative: CK 7 (usually) |
| Small-cell carcinoma (Lung) | Positive: TTF-1, high proliferative rate (Ki-67, MIB-1) \\ Variable: Chromogranin, synaptophysin |
| Neuroendocrine carcinoma (Lung) | Positive: Chromogranin, synaptophysin, epithelial stains |
| Germ cell tumor | Positive: HCG, AFP, Oct4 transcription factor, placental alkaline phosphatase, epithelial stains |
| Hepatocellular carcinoma | Positive: Hep par 1, CEA, AFP, glypican 3 \\ Negative: CK 7, CK 20 |
| Renal cell carcinoma | Positive: Pan keratin, CAM 5.2, Pax-8, CK 7, vimentin, RCC, CD 10 \\ Negative: CK 20, CEA |
| Prostate carcinoma | Positive: PSA, prostatic acid phosphatase \\ Negative: CK 7, 20 |
| Pancreas carcinoma | Positive: CA 19-9, CK 7, CDX-2, CK 17 \\ Variable: CK 20 |
| Breast carcinoma | Positive: ER, PR, Her-2-neu, CK 7, gross cystic fluid protein 15, epithelial stains, GATA 3, mammaglobin \\ Negative: CK 20 |
| Ovarian carcinoma | Positive: CK 7, WT-1, Pax-8, ER \\ Negative: CK 20, CDX-2 |
| Thyroid carcinoma | Positive: Thyroglobulin, TTF-1, CK 7 |