| Cytokeratin | EMA | LCA | S-100 | Desmin/vimentin | OCT 4/HCG/AFP/PLAP | Chromogranin/synaptophysin | |
|---|---|---|---|---|---|---|---|
| Carcinoma | + | + | - | S | - | S | S |
| Melanoma | -, R | - | - | + | + | - | - |
| Sarcoma | - | S | - | - | + | - | - |
| Lymphoma | - | -, R | + | - | - | - | - |
| Neuroendocrine carcinoma | + | + | - | - | - | - | + |
| Germ cell tumor | -, R | - | - | - | - | + | - |
S: sometimes positive
R: rarely positive
| Tumor type | Immunohistochemical staining |
|---|---|
| Carcinoma | Positive: Pankeratin, AE 1/3, CAM 5.2, OSCAR, EMA Negative: CD 45 Variable: CK 7, CK 20, S-100, vimentin |
| Colorectal carcinoma | Positive: CK 20, CDX-2 Negative: CK 7 |
| Adenocarcinoma (Lung) | Positive: TTF-1, napsin A, CK 7, mucicarmine, PAS-D Negative: Thyroglobulin |
| Squamous cell carcinoma (Lung) | Positive: p 40, p 63, CK 5/6, desmoglein Negative: CK 7 (usually) |
| Small-cell carcinoma (Lung) | Positive: TTF-1, high proliferative rate (Ki-67, MIB-1) Variable: Chromogranin, synaptophysin |
| Neuroendocrine carcinoma (Lung) | Positive: Chromogranin, synaptophysin, epithelial stains |
| Germ cell tumor | Positive: HCG, AFP, Oct4 transcription factor, placental alkaline phosphatase, epithelial stains |
| Hepatocellular carcinoma | Positive: Hep par 1, CEA, AFP, glypican 3 Negative: CK 7, CK 20 |
| Renal cell carcinoma | Positive: Pan keratin, CAM 5.2, Pax-8, CK 7, vimentin, RCC, CD 10 Negative: CK 20, CEA |
| Prostate carcinoma | Positive: PSA, prostatic acid phosphatase Negative: CK 7, 20 |
| Pancreas carcinoma | Positive: CA 19-9, CK 7, CDX-2, CK 17 Variable: CK 20 |
| Breast carcinoma | Positive: ER, PR, Her-2-neu, CK 7, gross cystic fluid protein 15, epithelial stains, GATA 3, mammaglobin Negative: CK 20 |
| Ovarian carcinoma | Positive: CK 7, WT-1, Pax-8, ER Negative: CK 20, CDX-2 |
| Thyroid carcinoma | Positive: Thyroglobulin, TTF-1, CK 7 |